Chris & Danny's House is where almost all of the series takes place. It is the main location of the series, however there are other locations. The house is the home of Chris & Danny and houses Chris's Room and Danny's Lair. In Infected, Part 3 Chris called the Construction Crew to remove Danny's Lair from the house completely and rid the house of any of Danny's inventions.
- In Infected, Part 3 it was revealed the address is 2318 Westchiester Street. However, this is a fictional address.